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This activity reviews the mechanism of action, adverse event profile, toxicity, dosing, pharmacodynamics, and monitoring of clonidine, pertinent for interprofessional team members when indicated for therapy.

It lowers blood pressure by reducing sympathetic outflow from the central nervous system. These receptors have autoinhibitory effects. Clonidine works by slowing the pulse rate and exerts a reduction of serum concentrations of renin, aldosterone, and catecholamines [20] clonidine may improve symptoms of attention deficit hyperactivity disorder in some people but causes many adverse effects and the beneficial effect is modest

2 it has a long duration of action as it is given twice daily and the therapeutic window is between 0.1mg and 2.4mg daily Clonidine is most commonly known for its antihypertensive action The patient’s blood pressure declines within 30 to 60 minutes after an oral dose, the maximum decrease occurring within 2 to 4 hours Clonidine has multiple uses across various medical conditions.

These receptors are part of the sympathetic nervous system, which is responsible for the body's fight or flight response.

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